A Novel Rapidly Disintegrating Tablet of Sildenafil Citrate with Enhanced Stability: Design and In-vitro Evaluation
نویسندگان
چکیده
This work aimed to formulate sildenafil citrate rapidly disintegrating tablets with enhanced stability utilizing the approach of incorporating antioxidant simultaneously with pH modifier for adjusting the tablet microenvironmental pH. Studies for effect of pH on the drug saturated solutions stability revealed that the drug exhibited maximum stability at pH 4.6. Studies for the effect of antioxidants on drug stability revealed marked stabilizing effect of sodium metabisulphite. Tablets were prepared by direct compression according to 2 2 factorial design considering the factors; filler and disintegrant types. All blends contained sodium metabisulphite as antioxidant and potassium dihydrogen phosphate as microenvironmental pH adjuster. Two-way ANOVA was performed to assess effects and interactions of formulation factors on tablets characteristics. Two selected formulae (F b and F ab) were subjected to storage at 50 oC/75 % R.H for 12 weeks, where no significant changes was observed for F ab, while marked discoloration was observed for F b. The results suggested that F ab could be a promising drug formulation with rapid disintegration and enhanced stability.
منابع مشابه
Aly and Mohammed: Preparation and Evaluation of Sildenafil Rapidly Disintegrating Tablets
Sildenafil citrate is an oral therapy for erectile dysfunction (ED). Sildenafil, a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5 (PDE5), has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. The main objective of this study is to prepare more effective, rapidly disintegrating and rapid onse...
متن کاملFormulation of New Sildenafil Citrate-caffeine Orally Disintegrating Tablets: in Vitro and in Vivo Evaluation
متن کامل
Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation
Sildenafil citrate (SC), a drug used to treat erectile dysfunction, is available in tablet form but has three major problems. First, the drug displays inadequate aqueous solubility, which delays the onset of its action. Second, the drug undergoes extensive first-pass metabolism, resulting in a low (40%) bioavailability. Third, the gastrointestinal effects of SC include dyspepsia and a burning s...
متن کاملFormulation and Evaluation of a Novel Matrix-Type Orally Disintegrating Ibuprofen Tablet
Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...
متن کاملFormulation and Evaluation of a Novel Matrix-Type Orally Disintegrating Ibuprofen Tablet
Orally disintegrating tablets (ODTs) are capable of turning quickly into a liquid dosage form in contact with the saliva, thus possessing the advantages of both the solid dosage forms particularly stability and liquid dosage forms specially ease of swallowing and pre-gastric absorption of drug. The aim of this study was to prepare a novel matrix-type buccal fast disintegrating ibuprofen tablet ...
متن کامل